Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis
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چکیده
منابع مشابه
Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis.
Leptin regulates energy balance and glucose metabolism by activation of multiple signaling cascades mediated by the long-form leptin receptor Ob-Rb. However, the whole spectrum of signaling actions through the 3 cytoplasmic tyrosines of mouse Ob-Rb remains to be completely defined in vivo. Here, we generated 2 knockin lines of mice expressing mutant leptin receptors with phenylalanine substitut...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2005
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2005.02.001